The bombings come days after air raids on Jabalia and Bureij refugee camps that authorities say killed more than 200 people.
The Israeli army bombed the Al-Maghazi refugee camp in central Gaza, killing more than 30 people, Palestinian officials said.
The victims of Saturday’s airstrike were taken to al-Aqsa Martyrs’ Hospital in Deir el-Balah, the Hamas-run enclave’s health ministry said in a statement.
The Palestinian Wafa news agency reported earlier that the attack killed 51 people, most of them women and children.
Al Jazeera could not independently confirm the number of casualties in the attack, which comes days after air raids on the Jabalia and Bureij refugee camps that Palestinian officials say killed more than 200 people.
The Israeli military did not respond to Al Jazeera’s request for comment.
However, a military spokesperson told the AFP news agency they were investigating whether their forces were operating in the area at the time.
The latest attacks came after the United States on Saturday rejected calls from Arab countries for an immediate ceasefire in the month-long conflict.
At a news conference with his Jordanian and Egyptian counterparts in Amman, U.S. Secretary of State Blinken said a full ceasefire “would leave Hamas in place to regroup and repeat its attacks.”
US President Joe Biden’s administration has instead proposed localized “humanitarian pauses” to facilitate the delivery of aid to Gaza and efforts to secure the release of captives held by Hamas.
Israeli Prime Minister Benjamin Netanyahu has rejected a temporary cessation of the war unless it involves the release of more than 240 Israelis and foreigners believed to have been taken prisoner by the Palestinian armed group.
Blinken is expected to continue his Middle East tour on Sunday – his second since the start of the war between Israel and Hamas – with a two-day visit to Turkey.
At least 9,488 Palestinians have been killed in Gaza since Israel launched its campaign to eliminate Hamas, according to Palestinian officials.
At least 1,430 people were killed and more than 240 others taken hostage during Hamas’ surprise attack on southern Israel on October 7, according to Israeli officials.